The ZRT Laboratory Blog

The ZRT Blog is an extensive resource for patients and health care providers searching for health and hormone testing information. Here, you can read about ZRT’s cutting edge research, advances in testing, wellness advice, and health industry highlights.

Research Updates – Trials of HRT Started in Early Menopause

Posted by Margaret Groves on Friday, 15 September

ThinkstockPhotos-520098512.jpg

One of the primary objectives of the Women's Health Initiative was to see if postmenopausal hormone replacement therapy (HRT) improved long-term risk of coronary heart disease, among other chronic diseases.

However, the combined estrogen/progestin (Prempro) arm was halted in 2002, citing that the participants’ risk of cardiovascular disease outweighed any potential benefit of HRT in the prevention of colorectal cancer and bone fracture [1]. The conjugated equine estrogen (CEE)-only arm was also halted in 2004 citing no improvement in heart disease risk but an increased incidence of stroke, and no benefit in terms of fractures, although there was a reduced breast cancer risk [2].

Yet the WHI investigators published a report this week [3] after a cumulative follow-up of 18 years finding that there was no overall increase in all-cause, cardiovascular, or cancer mortality as a result of either Prempro or CEE-only treatment during their participation in the trial.

Read More

How to Convert Patients to BHRT from Conventional Therapies

Posted by Jim Paoletti on Thursday, 23 March

doctor-explaining--319564-edited.jpg

Practice Takeaway: 

I always try to taper the estrogen dose down over a period of 2-6 months depending on the individual’s difficulty with withdrawal symptoms. Once I have the patient on a lower dose (Premarin 0.3 mg or Estrace 0.25 mg every other day at the most), I will switch over to a bi-est consisting of 50% estradiol and 50% estriol.

The reason for this is, if you stop the estrogen abruptly or decrease the dose too quickly, the patient can experience severe withdrawal symptoms of estrogen deficiency. 

Read More

Testosterone Replacement Therapy: Ensuring an Accurate Dose!

Posted by Jim Paoletti on Thursday, 07 July

scientists_deciding.jpgTestosterone replacement therapy has the potential to drastically improve quality of life of those who need it. However, many men who begin topical testosterone are given too much of the hormone.

Explanations for this erroneous tendency are rooted in incorrect dosing principles that have been established on false assumptions, misconceptions, invalid conclusions and aggressive marketing instead of physiology and science.

Why are testosterone replacement standards and prescribing processes so frequently misguided? 

Read More

Menopause – Is It All In Your Head?

Posted by Dr. Kate Placzek on Friday, 03 June

ThinkstockPhotos-486321414_lo.res.jpg

Estrogen. 

We've heard Dr. Zava call it the "angel of life, and the angel of death." Too much can be hazardous. Too little can be problematic also. 

Not many people realize this, but estrogen plays a role in more bodily functions than just reproduction. In fact, estrogen has many important functions in the brain. 

Studies show that decreasing levels of estrogen can cause two of the most common perimenopause symptoms hot flashes and mood fluctuations. Curious how this happens? Read on to learn the details of this biochemistry. 

Read More