The nervous system and its communication with peripheral organs is under the continuous dynamic influence of hormones, neuroactive steroids, and neurotransmitters. This is why the underlying pathology of mood disorders can often be varied and complex.
The hormonal piece is critical to our understanding of the imbalances when it comes to the complete neurotransmitter assessment. Hormones regulate key processes pertaining to neurotransmitter biosynthesis, signaling, and degradation. It is important to recognize that disturbances in the relationships between hormones and neurotransmitters can shape normal physiology toward a maladaptive state leading to suboptimal psychological wellbeing.